CXR’s collaborative and advisory approach, toxicological expertise and extensive laboratory capabilities have helped customers of all sizes resolve issues relating to the safety of compounds or selection of drug or chemical candidates.
Our customers include leading pharmaceutical, agrochemical, chemical, consumer product and biotechnology companies. We provide Investigative Toxicology, Exploratory & Discovery Toxicology, Metabolism & PK/TK and Dermal Absorption services and expertise on a contract research basis.
CXR employs over 35 staff recruited from both industrial and academic backgrounds, over 30% of whom have PhDs. The combination of academic excellence together with extensive industrial experience in pharmaceutical, agrochemical and chemical toxicology, metabolism and pharmacokinetics leads to a uniquely skilled investigative toxicology and preclinical development service.
To date, we have helped over 60 companies/consortia of all sizes across a broad range of different sectors including global pharmaceutical, biotech, agrochemical, consumer product, industrial chemical and fine chemical companies. These have included: BASF, Bayer, Dow Agrochemical, DuPont, Monsanto, Syngenta, ExxonMobil, AstraZeneca, Sanofi-Aventis, Pfizer, Roche, Procter & Gamble, Cancer Research Technology, Ineos Fluor, Ineos Chlor, 3M, Plastics Europe and ECPI.
Investigative and Mechanistic Toxicology
We design and perform experiments to explain observed toxicities, and evaluate the actual hazard and risk to humans…
Exploratory and Discovery Toxicology
We use mechanistic toxicology at the research stage to drive chemical design, candidate selection and translational risk assessment…
Metabolism and PK/TK Support
CXR works with agrochemical, chemical and pharmaceutical companies to generate PK/TK, absorption and metabolic profiling data…
CXR has provided exploratory toxicology and investigative toxicology services to the agrochemical industry for many years.
Pharmaceutical & Biotech
CXR works with pharmaceutical and biotechnology companies to support discovery toxicology and investigative toxicology programs.
CXR has provided investigative toxicology, metabolism, absorption and read-across services to the chemicals industry for many years.
CXR has expertise in elucidating potential mechanisms of toxicity of marketed consumer products, & of using primary cell culture and genomics to support product claims.
Cliff Elcombe, an Obituary
CLIFF ELCOMBE OBITUARY Dr Cliff Elcombe was a well-known and accomplished British toxicologist, who spent almost his entire career investigating the mechanisms of toxicity of various industrial chemicals and agrochemicals. He had an enviable reputation for his knowledge of, and insight into, non-genotoxic mechanisms of carcinogenesis and was internationally recognized for his work in predicting […]
It is with great sadness that we learned that our colleague Dr Cliff Elcombe died suddenly last Thursday, 25th August after a short illness. Cliff was co-founder and Research Director of CXR, and an internationally renowned toxicologist. Cliff played a huge role in the formation and success of CXR, as well as in the wider […]
CXR Biosciences strengthens mechanistic toxicology and industry expertise with the appointment of Professor Brian Lake
Professor Brian G Lake, BSc, PhD, DSc, FBTS has joined CXR Biosciences as an Associate Toxicologist. CXR Biosciences offers tailored preclinical services in the areas of investigative and mechanistic toxicology, exploratory and discovery toxicology, PK and metabolism and dermal absorbtion. Using its collaborative approach and industry expertise, CXR works with clients of all sizes to […]
CXR Biosciences gains GLP accreditation, launches in-vitro dermal absorption service following industry demand
CXR Biosciences, part of the Concept Life Sciences Group, has added in vitro dermal absorption studies to their already comprehensive portfolio of mechanistic toxicology and ADMET services. This is also the first service that CXR offers to formal Good Laboratory Practice (GLP) standards, following a successful audit by the MHRA on 23rd June. The purpose […]
Concept Life Sciences Group Event Success: Early Safety and Enhancing the Discovery Process Spotlight, London, UK
CXR Biosciences and Peakdale Molecular (members of the Concept Life Sciences Group) brought together a number of eminent speakers recently as part of their Spotlight Session series. The event, which was held at the Kohn Centre at the Royal Society in London focussed on current challenges in integrating safety testing into early drug, agrochemical and […]
New investigative toxicology research from CXR Biosciences: six posters to be co-presented at the upcoming Society of Toxicology conference in partnership with BASF, Adama, Monsanto and the H4R REACH consortium
CXR Biosciences, the investigative and exploratory toxicology company, is co-presenting six posters at the upcoming Society of Toxicology meeting in New Orleans on 13th – 17th March. This innovative research has been performed with several CXR customers including BASF, Adama, Monsanto and the H4R REACH consortium. Four posters describe studies performed at CXR to investigate […]