CXR

CXR’s collaborative and advisory approach, toxicological expertise and extensive laboratory capabilities have helped customers of all sizes resolve issues relating to the safety of compounds or selection of drug or chemical candidates.

Our customers include leading pharmaceutical, agrochemical, chemical, consumer product and biotechnology companies. We provide Investigative Toxicology, Exploratory & Discovery Toxicology, Metabolism &  PK/TK and Dermal Absorption services and expertise on a contract research basis.

CXR employs over 35 staff recruited from both industrial and academic backgrounds, over 30% of whom have PhDs. The combination of academic excellence together with extensive industrial experience in pharmaceutical, agrochemical and chemical toxicology, metabolism and pharmacokinetics leads to a uniquely skilled investigative toxicology and preclinical development service.

To date, we have helped over 60 companies/consortia of all sizes across a broad range of different sectors including global pharmaceutical, biotech, agrochemical, consumer product, industrial chemical and fine chemical companies. These have included: BASF, Bayer, Dow Agrochemical, DuPont, Monsanto, Syngenta, ExxonMobil, AstraZeneca, Sanofi-Aventis, Pfizer, Roche, Procter & Gamble, Cancer Research Technology, Ineos Fluor, Ineos Chlor, 3M, Plastics Europe and ECPI.

Services

Investigative and Mechanistic Toxicology

We design and perform experiments to explain observed toxicities, and evaluate the actual hazard and risk to humans…

Exploratory and Discovery Toxicology

We use mechanistic toxicology at the research stage to drive chemical design, candidate selection and translational risk assessment…

Metabolism and PK/TK Support

CXR works with agrochemical, chemical and pharmaceutical companies to generate PK/TK, absorption and metabolic profiling data…

Dermal absorption, metabolism and toxicity.

In vitro studies to predict human exposure, drive risk assessments and bioequivalence studies, and help select chemicals and formulations…

Industries

Agrochemical
Crop Protection

CXR has provided exploratory toxicology and investigative toxicology services to the agrochemical industry for many years.

Pharmaceutical & Biotech

CXR works with pharmaceutical and biotechnology companies to support discovery toxicology and investigative toxicology programs.

Chemical

CXR has provided investigative toxicology, metabolism, absorption and read-across services to the chemicals industry for many years.

Consumer products

CXR has expertise in elucidating potential mechanisms of toxicity of marketed consumer products, & of using primary cell culture and genomics to support product claims.

Latest News

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CXR Biosciences crowned ‘Science and Technology Business of the Year’ for the second year running

04.11.16

CXR Biosciences, part of the Concept Life Sciences Group, has been crowned winner of the ‘Science and Technology Business of the Year’ award at The Courier Business Awards for the second year running. The award was presented to the company on Saturday 29th October at an official awards ceremony which was held at The Apex […]

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CXR Biosciences to expand its mechanistic toxicology services following Scientific Advisory Board endorsement

29.09.16

CXR Biosciences, part of the Concept Life Sciences Group, held its second Scientific Advisory Board recently which focused on the mechanistic toxicology services required by the agrochemical, chemical, pharmaceutical and consumer products industries. CXR brought together experienced investigative toxicologists from across the various target industries to debate industry needs and emerging trends and how CXR […]

Cliff Elcombe, an Obituary

15.09.16

CLIFF ELCOMBE OBITUARY Dr Cliff Elcombe was a well-known and accomplished British toxicologist, who spent almost his entire career investigating the mechanisms of toxicity of various industrial chemicals and agrochemicals.  He had an enviable reputation for his knowledge of, and insight into, non-genotoxic mechanisms of carcinogenesis and was internationally recognized for his work in predicting […]

Announcement

30.08.16

It is with great sadness that we learned that our colleague Dr Cliff Elcombe died suddenly last Thursday, 25th August after a short illness. Cliff was co-founder and Research Director of CXR, and an internationally renowned toxicologist. Cliff played a huge role in the formation and success of CXR, as well as in the wider […]

CXR Biosciences strengthens mechanistic toxicology and industry expertise with the appointment of Professor Brian Lake

07.07.16

Professor Brian G Lake, BSc, PhD, DSc, FBTS has joined CXR Biosciences as an Associate Toxicologist. CXR Biosciences offers tailored preclinical services in the areas of investigative and mechanistic toxicology, exploratory and discovery toxicology, PK and metabolism and dermal absorbtion. Using its collaborative approach and industry expertise, CXR works with clients of all sizes to […]

CXR Biosciences gains GLP accreditation, launches in-vitro dermal absorption service following industry demand

29.06.16

CXR Biosciences, part of the Concept Life Sciences Group, has added in vitro dermal absorption studies to their already comprehensive portfolio of mechanistic toxicology and ADMET services.  This is also the first service that CXR offers to formal Good Laboratory Practice (GLP) standards, following a successful audit by the MHRA on 23rd June. The purpose […]