Investigative & Mechanistic Toxicology

We are experts in the design, performance and interpretation of preclinical investigative and mechanistic toxicology programs. These programs are typically intended to explain the toxicological mode of action / adverse outcome pathway (AOP) affected by the compound under investigation. Using this knowledge, we explain previously observed preclinical toxicities and evaluate the actual hazard and/or risk to humans.

We have experience of using experimental approaches to identify underlying AOPs in a broad range of organs and cell types.

Our experience spans the agrochemical, chemical, pharmaceutical and consumer products industries.  Mechanistic data generated at CXR are frequently used in regulatory submissions.

Our approach

CXR Biosciences will work with you to design comprehensive investigative safety studies. We typically use a hypothesis driven approach, for instance as outlined in the diagram below.

Invest-Flow

Stage 1:

  • Identify the basis for chemical induced toxicity observed in animal studies
  • A putative mechanism proposed for the mode of action (MOA)
  • A series of studies designed to test the hypothesis

Stage 2:

  • Develop an in vitro system to model the in vivo toxicity MOA

Stage 3:

  • Assess potential hazard to humans by evaluating MOA in human in vitro system

Areas of expertise at CXR include:

For further information about our services, or to discuss a specific issue, please contact us.

Download the Investigative & Mechanistic Toxicology brochure here