Pharmaceutical Target Safety Reviews
CXR toxicologists can support your pharmaceutical target safety literature reviews.
The aims of a target safety literature review include:
- Identify potential on-target toxicities
- Define the early discovery experiments required to evaluate potential target-related safety issues (using tool compounds). This might also include the identification of potential biomarkers of safety/toxicity to be used in preclinical studies (e.g. blood markers or gene expression profiles), and identification of relevant preclinical species
- Inform the design of subsequent regulatory safety studies
At CXR, target safety reviews are carried out by our experienced toxicologists and biochemists, rather than using a purely automated bioinformatics approach. A target safety literature review will draw on some or all of the following sources:
- Scientific literature (e.g. tissue expression & distribution, protein function, effects in gene knockout models, effects in relevant disease models)
- Known toxicological effects (preclinical and clinical) of reference and competitor compounds
- Bioinformatics support, e.g. Ingenuity pathways analysis
Importantly, CXR’s extensive preclinical laboratory capabilities mean that we can support the entire target safety review process, by if necessary designing and running experiments to assess potential target-related safety issues.
For further information about our target safety review services, or to discuss a specific issue, please contact us.