Endocrine Disruption Assays
Regulatory agencies are increasingly concerned about the potential for pesticides and other chemicals to act as endocrine disruptors.
Evidence suggests that the endocrine systems of certain fish and wildlife have been affected by chemical contaminants, resulting in developmental and reproductive problems. It is therefore suggested that novel chemicals (and those due for re-registration) are tested for their potential to disrupt the human and animal estrogen, androgen and thyroid hormone systems.
An in vitro screening process can be used to identify chemicals that have the potential to interact with the endocrine system. CXR has the industrial toxicological expertise to design your screening cascade. We offer the following in vitro endocrine assays, and can establish others on request:
- Aromatase (CYP19) inhibition – human and rat
- Lanosterol 14α-demethylase (CYP51) inhibition – human and rat
- Estrogen Receptor alpha Transactivation (agonism and antagonism) – human
- Estrogen Receptor beta Transactivation (agonism and antagonism) – human
- Androgen Receptor Transactivation (agonism and antagonism) – human
For further information about our investigative endocrine disruption screening services, or to discuss a specific issue, please contact us.