Agrochemical Exploratory Toxicology
Integrating mechanistic toxicology into candidate selection.
Exploratory toxicology studies are those carried out prior to selection of a development candidate. The primary aims of exploratory toxicology are:
- to drive the selection of the development candidate with the optimal toxicological properties, and to ensure acute toxicity thresholds are likely to be met
- to predict the toxicities likely to be seen in later regulatory studies, in order to ensure that suitable mechanistic endpoints can be included in those studies
- to use toxicokinetic (TK) data to understand the relationship between dose and systemic exposure, and if possible to identify potential inflection point doses for onset of non-linear toxicokinetic behaviour (the KMD, or Kinetically-derived Maximum Dose).
Exploratory Toxicology – the CXR Biosciences approach
CXR Biosciences has an extensive track record in exploratory toxicology, having supported the programmes of leading agrochemical companies for many years. We understand the scientific and industry context in which the studies are performed, and our flexible scheduling means we can deliver quality data in the short timeframes demanded by an agrochemical research organisation.
A typical exploratory toxicology program will have two to four key components:
CXR can run individual studies, or support entire programmes by:
- reviewing potential (e.g. on-target) or observed toxicity issues
- developing an hypothesis and consequent experimental programme
- performing the required experiments
- understand translational risk assessment, and drive chemical design and/or candidate selection