Exploratory & Discovery Toxicology

In order to improve R&D productivity, identification of potential toxic hazard and quantification of potential risk is shifting from the development stage to the research stage of R&D – hence this discipline is also termed predictive toxicology.

The aims of Exploratory & Discovery Toxicology are broadly:

  • to drive the chemical evolution and selection of the development candidate with the optimal toxicological properties
  • to predict the toxicities likely to be seen in later regulatory studies, in order to help select appropriate doses, and ensure that suitable mechanistic endpoints can be included in those studies

CXR Biosciences has an extensive track record in Exploratory & Discovery toxicology, having supported such programmes for many years.  We understand the scientific and industry context in which the studies are performed, and our flexible scheduling means we can deliver quality data in the short timeframes demanded by your research organisation.  We have particular experience in:

CXR can run individual studies, or support entire programmes by:

  • reviewing potential (e.g. on-target) or observed toxicity issues
  • developing an hypothesis and consequent experimental programme
  • performing the required experiments
  • understanding translational risk assessment, and driving chemical design and/or candidate selection

This approach can be applied to assess both on-target and off-target toxicities.  If required we can build and deploy novel mechanistic assays for screening of candidate compounds, in order to provide comparative data on toxicological risk that can be used to drive further chemistry. We can also design and run appropriate screening programmes for e.g. mitochondrial toxicity and endocrine disruption.

For further information about our services, or to discuss a specific issue, please contact us.