Publications

CXR Biosciences
Authors: Luisier R, Lempiäinen H, Scherbichler N, Braeuning A, Geissler M, Dubost V, Müller A, Scheer N, Chibout SD, Hara H, Picard F, Theil D, Couttet P, Vitobello A, Grenet O, Grasl-Kraupp B, Ellinger-Ziegelbauer H, Thomson JP, Meehan RR, Elcombe CR, Henderson CJ, Wolf CR, Schwarz M, Moulin P, Terranova R, Moggs JG
Patent:
DOI: 10.1093/toxsci/kfu038
CXR Biosciences
Authors: Kerstin Reisingera, Sebastian Hoffmannb, Nathalie Alépéec, Takao Ashikagad, Joao Barrosoe, Cliff Elcombe, Nicola Gellatlyg, Valentina Galbiatih, Susan Gibbsi, Hervé Grouxj, Jalila Hibatallahk, Donald Keller, Petra Kernm, Martina Klarice, Susanne Kollen, Jochen Kuehnlo, Nathalie Lambrechtsp, Malin Lindstedtq, Marion Milletr, Silvia Martinozzi-Teissierc, Andreas Natschs, Dirk Petersohna, Ian Piket, Hitoshi Sakaguchiu, Andreas Schepkyo, Magalie Tailhardatv
Patent:
DOI: 10.1016/j.tiv.2014.10.018
CXR Biosciences
Authors: Braeuning A, Gavrilov A, Brown S, Wolf CR, Henderson CJ, Schwarz M
Patent:
DOI: 10.1093/toxsci/kfu099
CXR Biosciences
Authors: Matthew J. LeBaron, David R. Geter, Reza J. Rasoulpour, B. Bhaskar Gollapudi, Johnson Thomas, Jennifer Murray, H. Lynn Kan, Amanda J. Wood, Cliff Elcombe, Audrey Vardy, Jillian McEwan, Claire Terry, Richard Billington
Patent:
DOI: doi:10.1016/j.taap.2013.04.009
CXR Biosciences
Authors: Plummer S., Dan D., Quinney J., Hallmark N., Phillips RD., Millar M., Macpherson S., Elcombe CR
Patent:
DOI: 10.1093/toxsci/kft016
CXR Biosciences
Authors: Elcombe C., Peffer R., Wolf D., Bailey J., Bars R., Bell D., Cattley R., Ferguson S., Geter D., Goetz A., Goodman J., Hester S., Jacobs A., Omiecinski C., Schoeny R., Xie W., Lake B
Patent:
DOI: 10.3109/10408444.2013.835786
CXR Biosciences
Authors: Lempiäinen H, Couttet P, Bolognani F, Müller A, Dubost V, Luisier R, Del Rio, Espinola A, Vitry V, Unterberger EB, Thomson JP, Treindl F, Metzger U, Wrzodek C, Hahne F, Zollinger T, Brasa S, Kalteis M, Marcellin M, Giudicelli F, Braeuning A, Morawiec L, Zamurovic N, Längle U, Scheer N, Schübeler D, Goodman J, Chibout SD, Marlowe J, Theil D, Heard DJ, Grenet O, Zell A, Templin MF, Meehan RR, Wolf RC, Elcombe CR, Schwarz M, Moulin P, Terranova R, Moggs JG
Patent:
DOI: 10.1093/toxsci/kfs303
CXR Biosciences
Authors: Elcombe CR, Elcombe BM, Foster JR, Chang S-C, Ehresmanc DJ, Noker PE and Butenhoff JL
Patent:
DOI: 10.1016/j.tox.2011.12.015
CXR Biosciences
Authors: Donaldson K., Schinwald A., Murphy F., Cho W.S., Duffin R., Tran L., Poland C
Patent:
DOI: 10.1021/ar300092y
CXR Biosciences
Authors: Wu, McDonald, Liu, Chaguturu, Klaassen
Patent:
DOI:
CXR Biosciences
Authors: A.P. Hall, C. R. Elcombe, J. R. Foster, T. Harada, W. Kaufmann, A. Knipple, K. Kutttler, D. E. Malarkey, R. R. Maronpot, A. Nishikawa, T. Nolte, A. Schulte, V. Strauss and M. J. York
Patent:
DOI: 10.1177/0192623312448935
CXR Biosciences
Authors: N. Scheer, P. Balimane, M.D. Hayward, S. Buechel, G. Kauselmann, C.R Wolf
Patent:
DOI: 10.1124/dmd.112.047605
CXR Biosciences
Authors: N. Scheer, Y. Kapelyukh, L. Chatham, A. Rode, S. Buechel, C.R. Wolf
Patent:
DOI:
CXR Biosciences
Authors: Scheer N, Kapelyukh Y, McEwan J, Beuger V, Stanley LA, Rode A and Wolf CR
Patent:
DOI: 10.1124/mol.111.075192
CXR Biosciences
Authors: Boverhof DR, Chamberlain MP, Elcombe CR, Gonzalez FJ, Heflich RH, Hernández LG, Jacobs AC, Jacobson-Kram D, Luijten M, Maggi A, Manjanatha MG, Benthem J, Gollapudi BB
Patent:
DOI: 10.1093/toxsci/kfr075
CXR Biosciences
Authors: Hasegawa M, Kapelyukh Y, Tahara H, Seibler J, Rode A, Krueger S, Lee DN, Wolf CR, Scheer N
Patent:
DOI: 10.1124/mol.111.071845
CXR Biosciences
Authors: Elcombe CR, Elcombe BM, Foster JR, Farrar DG, Jung R, Chang S-C, Kennedy GL and L. Butenhoff JL
Patent:
DOI: 10.1007/s00204-010-0572-2
CXR Biosciences
Authors: Warnasuriya GD, Elcombe BM, Foster J and Elcombe CR
Patent:
DOI: 10.1007/s00204-009-0489-9
CXR Biosciences
Authors: Ross, J., Plummer, S., Rode, A., Scheer, N S., Vogel, O., Wolf, C.R., and Elcombe, C
Patent:
DOI: 10.1093/toxsci/kfq118
CXR Biosciences
Authors: Skare JA, Hewitt NJ, Doyle E, Powrie R, Elcombe C
Patent:
DOI: 10.3109/00498250903134443
CXR Biosciences
Authors: Scheer N, Ross J, Kapelyukh Y, Rode A and Wolf CR
Patent:
DOI: 10.1093/toxsci/kft016
CXR Biosciences
Authors: Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, and Wolf CR
Patent:
DOI: 10.1172/JCI35483
CXR Biosciences
Authors: Hay DC, Zhao D, Fletcher J, Hewitt ZA, McLean D, Urruticoechea-Uriguen A, Black JR, Elcombe C, Ross JA, Wolf R and Cui W
Patent:
DOI: 10.1634/stemcells.2007-0718
CXR Biosciences
Authors: Stanley LA, Skare JA, Doyle E, Powrie R, D’Angelo D and Elcombe CR
Patent:
DOI: 10.1016/j.tox.2005.01.019
CXR Biosciences
Authors: Seacat AM, Thomford PJ, Hansen KJ, Clemen LA, Eldridge SR, Elcombe CR and John L. Butenhoff
Patent:
DOI: 10.1016/S0300-483X(02)00511-5
CXR Biosciences
Authors: Butenhoff J, Costa G, Elcombe C, Farrar D, Hansen C, Iwai H, Jung R, Kennedy G, Lieder P, Olsen G and Thomford P
Patent:
DOI: 10.1093/toxsci/69.1.244

Poster Presentations

Characterisation Of The Hepatic Effects Of Phenobarbital (Pb) And Pregnenolone16A-Carbonitrile(Pcn) In Constitutive Androstanereceptor (Car, Nr1I3) And Pregnanex Receptor (Pxr, Nr1I2) Double Knockout Rats. This poster was presented at SOT 2016

Use Of Two Compounds To Validate Wild-Type (Wt) And Constitutive Androstane Receptor (Car) Knockout Rat Hepatocyte Cultures This poster was presented at SOT 2016

An In-Vitro Absorption Screen With Rosin/Resins Using Everted Rat Intestinal Sacs This poster was presented at SOT 2016

Further Evaluation Of The Car/Pxr Moa And Human Relevance Of Silthiofam-Induced Rat Liver Tumours. This poster was presented at SOT 2016

Prochloraz: Further In Vitro Data Comparing Responses In Male Wild-Type Mouse And Human Cultured Hepatocytes Completes The Human Relevance Framework This poster was presented at SOT 2016

Mouse Liver Tumors Induced by Prochloraz Have a CAR-Like Mode of Action and Are Not Relevant to Humans. This poster was presented at SOT 2015 with BASF SE

The Inhibition of the Intestinal Absorption of Vitamin K by a Medium-Chain Chlorinated Paraffin (MCCP) in an In Vitro Everted Rat Intestinal Sac Model.  This poster was presented at SOT 2015 with CCERT Ltd

Characterisation of the hepatic effects of phenobarbital in Constitutive Androstane Receptor (CAR, NR1I3) knockout rats.  This poster was presented at Eurotox 2014

Characterisation of the hepatic effects of pregnenolone 16a- carbonitrile (PCN) in Pregnane X Receptor (PXR, NR1I2) knockout rats.  This poster was presented at Eurotox 2014

Differential Dose-Response Relationships For Hepatic Cyp2b10 Induction And Cell Proliferation In Wild Type Mice And Mice Humanised (huPXR/huCAR) For The Constitutive Androstane Receptor (CAR) And Pregnane X Receptor (PXR) Administered Phenobarbitone (PB).  This poster was presented at Eurotox 2014

The use of everted rat small intestinal sacs in vitro to estimate relative absorption potential of a series of alpha olefins.  This poster was presented at Eurotox 2014

Investigations with a humanised CYP3A4/3A7 mouse model.  This poster was presented at Eurotox 2014

An evaluation of the mode of action(MOA) and human relavance of rat liver tumours oserved in a chronic rat feeding study with silthiofam.  This poster was presented at Eurotox 2014 with Monsanto

Characterisation of the hepatic effects of phenobarbital in Constitutive Androstane Receptor (CAR, NR1I3) knockout rats.  This poster was presented at SOT 2014

The Use Of An Oxidative Stress Associated in vitro Screen For The Prediction Of Potential Nanoparticle Toxicity. The poster was presented at Nanomedicine 2013

Immunohistochemical and ChIP microarray analysis of peroxisome proliferator activated receptor alpha (PPARa) in fetal rat testes exposed in utero to dibutylphthalate.  This poster was presented at SOT 2011.

An investigation of the clearance of 14-C labelled vitamin K in control and MCCP-treated female CD rats.  This poster was presented at SOT 2011.

The effects of tris (2-ethylhexyl) trimellitate (TOTM) on gene expression associated with testicular mal-development (TMD) in rat foetal testes.  This poster was presented at SOT 2011.

Transcript Profiling of PXR and CAR Knock-out and Humanized Mouse Liver Provides Insight into Endogenous Roles of the Human PXR/CAR Isoforms

An In vitro Model for the Prediction of Chemical Metabolism and Toxicity

In vitro screening of a series of fluoropropenes and fluorocyclopropenes for hepatic s-glutathione conjugation and NADPH dependent oxidation.  This poster was presented at the International Congress of Toxicology, Montreal, 2007

Overview of Mechanistic Research on Perfluorinated Alkyl Acids with Emphasis on the Potential Value of New Technologies and Bio-Informatics in Elucidating Modes of Action.  This poster was presented at the British Toxicology Society Perfluorooctanoic Acid Workshop, 5th-6th November 2007

Laser Microdissection Targetted Transcription profiling and Pathways Analysis for Mechanism Based Hazard Assessment.  This poster was presented at the Toxicogenomics Meeting, Nice, 1st October 2007

Comparison of Gene Expression Changes in Whole Pancreas With Isolated Pancreatic acinar cells of rats fed diets containing Wyeth 14,643 or Ammonium Perfluorooctanoate (APFO)  This poster was presented at the British Toxiocology Society Annual Congress, 15-18th April 2007

Characterisation of APFO Induced Hepatomegaly in Rats  This poster was presented at the British Toxiocology Society Annual Congress, 15-18th April 2007

In vitro metabolites of Arylamine hair dyes in human hepatic microsomes and human hepatocyte  This poster was presented at Society of Toxicology, 46th Annual Meeting and Tox Expo, 25-29th March 2007

Comparison of 1-colour and 2-colour methods for microarray-based transcription profiling analysis with laser captured micro-dissected analysis  This poster was presented at Society of Toxicology, 46th Annual Meeting and Tox Expo, 25-29th March 2007

Identification of region specific gene expression changes and signalling pathways affected by Di-butyl-phthalate in foetal rat testes  This poster was presented at Society of Toxicology, 46th Annual Meeting and Tox Expo, 25-29th March 2007

Medium-chain chlorinated paraffin (MCCP)-induced haemorrhagic lesions in neonatal Sprague-Dawley rats. A role for altered vitamin K disposition?  Society of Toxicology 2005

The Effects of Ammonium Perfluorooctanoate (APFO) on the Transcriptional Profile of Pancreas and Liver of Male Rats

High Throughput Inhibition Screening of Five Major Human cytochrome P450 Enzymes using an In vitro Substrate cocktail

Hepatic Metabolism of Aromatic Amine Hair Dye Components as Compared with that of 2-Aminofluorine

Different Effects of PPAR alpha and PPAR gamma Agonists on Hepatocytes S-phase and Apoptosis