Publications

• Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not he hyperplastic response to the murine non-genotoxic hepatocarinogens phenobarbital and chlordane in vivo. ., Ross, J., Plummer, S., Rode, A., Scheer, N S., Vogel, O., Wolf, C.R., and Elcombe, C., (2010) epub J. Tox. Sci..

• In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice. Scheer N, Ross J, Kapelyukh Y, Rode A and Wolf CR, (2009)

> Access paper here DMD on-line FASTFORWARD.

• A Novel Panel of Mouse Models to Evaluate the Role of Human Pregnane X Receptor and Constitutive Androstane Receptor in Drug Response. Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, and Wolf CR ,(2008)The Journal of Clinical Investigation 118(9), pp3228–3239.

>  Access paper here.

• Time-Dependent and Compartment-Specific Effects of In Utero Exposure to Di(n-butyl) Phthalate on Gene/Protein Expression in the Fetal Rat Testis as Revealed byTranscription Profiling and Laser Capture Microdissection. Plummer S, Sharpe RM, Hallmark N, Mahood IK, Elcombe C,  (2007)Toxicological Sciences 97(2), pp520–532.

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Poster Presentations (2008-2009)

• A Novel CYP3A Cluster Humanized Mouse Model For Improved Prediction of Human Response. The poster was presented at ISSX 2009, Lisbon.
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• Genentech poster demonstrating use of the HRN™ mouse, with and without the CYP450 inhibitor ABT, to determine effects of hepatic vs. extrahepatic CYP 450 metabolism on bioavailability. The poster was presented at ISSX 2009.
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SOT 48th Annual meeting & ToxExpo™, 15-19th March 2009

• Transcript Profiling of PXR and CAR Knock-out and Humanized Mouse Liver Provides Insight into Endogenous Roles of the Human PXR/CAR Isoforms.
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ECETOC Annual Technical meeting, Brussels, 9-10th June 2009

• Human Constitutive Androstane Receptor (CAR) Supports The Hypertrophic but Not the Hyperplastic Response to the Murine Non-genotoxic Carcinogen Phenobarbital  in vivo
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British Toxiocology Society Annual Congress, University of Warwick, Coventry, 22-25th March 2009

• An In vitro Model for the Prediction of Chemical Metabolism and Toxicity
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10th European ISSX meeting, Vienna, Austria, 18-21st May 2008

• A Novel Panel of Double "Humanised" & Knockout PXR and CAR Mouse Models
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Oral Presentations 2007

British Toxicology Society Perfluorooctanoic Acid Workshop, Shrigley Hall, Cheshire, 5th-6th November 2007 Dr Cliff Elcombe

• Overview of Mechanistic Research on Perfluorinated Alkyl Acids with Emphasis on the Potential Value of New Technologies and Bio-Informatics in Elucidating Modes of Action.
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Toxicogenomics Meeting, Nice, 1st October 2007 Dr Simon Plummer

• Laser Microdissection Targetted Transcription profiling and Pathways Analysis for Mechanism Based Hazard Assessment.
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Poster Presentations (2007)

British Toxiocology Society Annual Congress, University of Surrey, Guildford, 15-18th April 2007

• Comparison of Gene Expression Changes in Whole Pancreas With Isolated Pancreatic acinar cells of rats fed diets containing Wyeth 14,643 or Ammonium Perfluorooctanoate (APFO)
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• Characterisation of APFO Induced Hepatomegaly in Rats
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Society of Toxicology, 46th Annual Meeting and Tox Expo, Charlotte, NC, 25-29th March 2007

• Improved "Humanised" PXR and CAR Mouse Models
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• In vitro metabolites of Arylamine hair dyes in human hepatic microsomes and human hepatocyte
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• Comparison of 1-colour and 2-colour methods for microarray-based transcription profiling analysis with laser captured micro-dissected analysis
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• Identification of region specific gene expression changes and signalling pathways affected by Di-butyl-phthalate in foetal rat testes
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General Poster Presentations

• Comparison of 1 cycle and 2 cycle RNA Labelling Methods for Microarray-based Transcription Profiling Analysis with Laser Capture Microdissected Samples
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• The Effects of Ammonium Perfluorooctanoate (APFO) on the Transcriptional Profile of Pancreas and Liver of Male Rats
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• High Throughput Inhibition Screening of Five Major Human cytochrome P450 Enzymes using an In vitro Substrate cocktail
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• Hepatic Metabolism of Aromatic Amine Hair Dye Components as Compared with that of 2-Aminofluorine
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• Novel PXR/CAR Humanised Mouse Models to predict Human Drug Disposition and Toxicity
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• Different Effects of PPAR alpha and PPAR gamma Agonists on Hepatocytes S-phase and Apoptosis
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