Publications
A Novel Panel of Mouse Models to Evaluate the Role of Human Pregnane X Receptor and Constitutive Androstane Receptor in Drug Response. Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, and Wolf CR ,(2008)The Journal of Clinical Investigation 118(9), pp3228–3239.
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Time-Dependent and Compartment-Specific Effects of In Utero Exposure to Di(n-butyl) Phthalate on Gene/Protein Expression in the Fetal Rat Testis as Revealed byTranscription Profiling and Laser Capture Microdissection. Plummer S, Sharpe RM, Hallmark N, Mahood IK, Elcombe C, (2007)Toxicological Sciences 97(2), pp520–532.
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Poster Presentations (2008-2009)
SOT 48th Annual meeting & ToxExpo™, 15-19th March 2009
- Transcript Profiling of PXR and CAR Knock-out and Humanized Mouse Liver Provides Insight into Endogenous Roles of the Human PXR/CAR Isoforms.
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ECETOC Annual Technical meeting, Brussels, 9-10th June 2009
- Human Constitutive Androstane Receptor (CAR) Supports The Hypertrophic but Not the Hyperplastic Response to the Murine Non-genotoxic Carcinogen Phenobarbital in vivo
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British Toxiocology Society Annual Congress, University of Warwick, Coventry, 22-25th March 2009
- An In vitro Model for the Prediction of Chemical Metabolism and Toxicity
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10th European ISSX meeting, Vienna, Austria, 18-21st May 2008
- A Novel Panel of Double "Humanised" & Knockout PXR and CAR Mouse Models
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Oral Presentations 2007
British Toxicology Society Perfluorooctanoic Acid Workshop, Shrigley Hall, Cheshire, 5th-6th November 2007 Dr Cliff Elcombe
- Overview of Mechanistic Research on Perfluorinated Alkyl Acids with Emphasis on the Potential Value of New Technologies and Bio-Informatics in Elucidating Modes of Action.
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Toxicogenomics Meeting, Nice, 1st October 2007 Dr Simon Plummer
- Laser Microdissection Targetted Transcription profiling and Pathways Analysis for Mechanism Based Hazard Assessment.
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Poster Presentations (2007)
British Toxiocology Society Annual Congress, University of Surrey, Guildford, 15-18th April 2007
- Comparison of Gene Expression Changes in Whole Pancreas With Isolated Pancreatic acinar cells of rats fed diets containing Wyeth 14,643 or Ammonium Perfluorooctanoate (APFO)
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- Characterisation of APFO Induced Hepatomegaly in Rats
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Society of Toxicology, 46th Annual Meeting and Tox Expo, Charlotte, NC, 25-29th March 2007
- Improved "Humanised" PXR and CAR Mouse Models
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- In vitro metabolites of Arylamine hair dyes in human hepatic microsomes and human hepatocyte
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- Comparison of 1-colour and 2-colour methods for microarray-based transcription profiling analysis with laser captured micro-dissected analysis
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- Identification of region specific gene expression changes and signalling pathways affected by Di-buty-phthalate in foetal rat testes
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General Poster Presentations
- Comparison of 1 cycle and 2 cycle RNA Labelling Methods for Microarray-based Transcription Profiling Analysis with Laser Capture Microdissected Samples
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- The Effects of Ammonium Perfluorooctanoate (APFO) on the Transcriptional Profile of Pancreas and Liver of Male Rats
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- High Throughput Inhibition Screening of Five Major Human cytochrome P450 Enzymes using an In vitro Substrate cocktail
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- Hepatic Metabolism of Aromatic Amine Hair Dye Components as Compared with that of 2-Aminofluorine
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- Novel PXR/CAR Humanised Mouse Models to predict Human Drug Disposition and Toxicit
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- Different Effects of PPAR alpha and PPAR gamma Agonists on Hepatocytes S-phase and Apoptosis
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