CXR Biosciences is continually developing innovative models for toxicological and pharmacological research.
We currently have the following technologies available for licensing.
HRN™ Mouse : This mouse lacks hepatic cytochrome P450 reductase and thus does not have P450 activity in the liver. The absence of phase 1 drug metabolism makes this model useful in investigating the role of drug metabolism in determining efficacy and toxicity of compounds. more....
Humanised Mouse models : We are developing a range of models in which the murine genes involved in drug metabolism and drug disposition are being replaced by human genes. Effects of test compounds in these models will therefore more accurately reflect the human situation. more....
PXR humanised mouse model : The PXR 'xenoreceptor' is an important determinant of the efficacy and toxicity of compounds, and is known to be responsible for species differences in the response to drugs.
Other humanised models will shortly become available (early 2008) once the validation studies have been completed. These include; CAR, PXR & CAR, CYP3A4, MDR-1, MRP-2.
Cell toxicity reporters : In vitro cell reporter systems have been developed to report on various biochemical mechanisms involved in the cellular response to toxic agents. These include;
Transactivation assays : Several transactivation assays have been developed to measure the activation of specific nuclear hormone receptors by test compounds. These have been developed to investigate the species differences in toxicity mediated through interaction with these receptors assays. We can custom design and build assays like this to investigate particular mechanistic issues to address the client's specific requirements.
Please contact us if you would like to discuss any of these licensing opportunities or find out how you can access these technologies as part of a fee for service contract.
