Home
|

The HRN™ Mouse

The Hepatic Reductase Null (HRN™ ) mouse

The HRN™ mouse lacks cytochrome P450 activity in the liver and thus provides an elegant tool for determining the role of hepatic P450 metabolism in drug disposition in vivo

More rapid

A single bioavailability study using the HRN™ mouse can provide information as to whether a test compound is metabolised by cytochrome P450s and whether parent or metabolite is responsible for efficacy or toxicity.  The model provides a means for establishing in vivo activity in the absence of first pass metabolism.  Further, this model can be crossed into disease models to facilitate a concomitant evaluation of pharmacological action and drug metabolism.

More informative

This model facilitates determination of phase II drug metabolism and identifies the importance of extrahepatic metabolism in drug disposition.  The HRN has uniquely advantages in toxicokinetic studies, in correlating drug dose with pharmacological effects and/or toxicity, and can also be used to determine the optimal route of administration.The HRN™ mouse has many applications in drug discovery and development:

EXAMPLE APPLICATIONS  - CLICK HERE

  • Determination of the role of hepatic metabolism in drug disposition, efficacy, and toxicity, of test compounds in a single experiment.
  • Evaluation of the in vivo pharmacological potency of molecules without first pass metabolism.
  • Quick determination of the significance of extrahepatic drug metabolism.
  • Assessment of the role of Phase II drug metabolism in drug disposition.
  • Evaluation of the role of drug transporters in drug uptake and efflux.
  • Determination of  whether an active metabolite is responsible for the in vivo pharmacological action.

The HRN™ mouse brochure

 Download pdf file

 

TECHNOLOGIES
The HRN™ Mouse
Generation
Phenotype
Example Applications
Future Developments
Access to HRN
Humanised Models
Engineered Biomarker models
Transactivation Assays
Engineered Biomarker cell lines
Transcription Profiling
Pathway Analysis
ADME assays - Hits to Leads
Licensing Opportunities
 

© Copyright CXR Biosciences Scotland 2007 | James Lindsay Place, Dundee Technopole, Dundee, Scotland DD1 5JJ Tel +44 1382 432163
Web Design, Development and hosting by MTC Media